2FGC: Crystal Structure Of Acetolactate Synthase- Small Subunit From Thermotoga Maritima

Crystal structures of two orthologs of the regulatory subunit of acetohydroxyacid synthase III (AHAS, EC from Thermotoga maritima (TM0549) and Nitrosomonas europea (NE1324) were determined by single-wavelength anomalous diffraction methods with the use of selenomethionine derivatives at 2.3 A and 2.5 A, respectively. TM0549 and NE1324 share the same fold, and in both proteins the polypeptide chain contains two separate domains of a similar size. Each protein contains a C-terminal domain with ferredoxin-type fold and an N-terminal ACT domain, of which the latter is characteristic for several proteins involved in amino acid metabolism. The ferredoxin domain is stabilized by a calcium ion in the crystal structure of NE1324 and by a Mg(H2O)(6)2+ ion in TM0549. Both TM0549 and NE1324 form dimeric assemblies in the crystal lattice.
PDB ID: 2FGCDownload
MMDB ID: 37738
PDB Deposition Date: 2005/12/21
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2FGC: dimeric; determined by author and by software (PISA,PQS)
Molecular Components in 2FGC
Label Count Molecule
Proteins (2 molecules)
Acetolactate Synthase, Small Subunit(Gene symbol: ilvH)
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

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