2FDD: Crystal Structure Of Hiv Protease D545701 Bound With Gw0385

A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clinical candidate GW0385.
PDB ID: 2FDDDownload
MMDB ID: 37729
PDB Deposition Date: 2005/12/13
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.58  Å
Source Organism:
Similar Structures:
Biological Unit for 2FDD: dimeric; determined by author and by software (PISA)
Molecular Components in 2FDD
Label Count Molecule
Proteins (2 molecules)
Gag-pol Polyprotein
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB