2F9B: Discovery Of Novel Heterocyclic Factor Viia Inhibitors

Citation:
Abstract
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
PDB ID: 2F9BDownload
MMDB ID: 37723
PDB Deposition Date: 2005/12/5
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 2.54  Å
Source Organism:
Similar Structures:
Biological Unit for 2F9B: trimeric; determined by author and by software (PISA)
Molecular Components in 2F9B
Label Count Molecule
Proteins (3 molecules)
1
Coagulation Factor VII(Gene symbol: F7)
Molecule annotation
1
Coagulation Factor VII(Gene symbol: F7)
Molecule annotation
1
Tissue Factor(Gene symbol: F3)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.