2ESV: Structure Of The Hla-E-VmaprtlilKK50.4 TCR COMPLEX

In contrast to antigen-specific immunity orchestrated by major histocompatibility complex (MHC) class Ia molecules, the ancestrally related nonclassical MHC class Ib molecules generally mediate innate immune responses. Here we have demonstrated the structural basis by which the MHC class Ib molecule HLA-E mediates an adaptive MHC-restricted cytotoxic T lymphocyte response to human cytomegalovirus. Highly constrained by host genetics, the response showed notable fine specificity for position 8 of the viral peptide, which is the sole discriminator of self versus nonself. Despite the evolutionary divergence of MHC class Ia and class Ib molecules, the structure of the T cell receptor-MHC class Ib complex was very similar to that of conventional T cell receptor-MHC class Ia complexes. These results emphasize the evolutionary 'ambiguity' of HLA-E, which not only interacts with innate immune receptors but also has the functional capacity to mediate virus-specific cytotoxic T lymphocyte responses during adaptive immunity.
PDB ID: 2ESVDownload
MMDB ID: 38172
PDB Deposition Date: 2005/10/27
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 2ESV: pentameric; determined by author
Molecular Components in 2ESV
Label Count Molecule
Proteins (5 molecules)
HLA Class I Histocompatibility Antigen, Alpha Chain E(Gene symbol: HLA-E)
Molecule annotation
Beta-2-microglobulin(Gene symbol: B2M)
Molecule annotation
Vmaprtlil Peptide From CMV Gpul40
Molecule annotation
Kk50.4 T Cell Receptor Alpha Chain(Gene symbol: TRAC)
Molecule annotation
Kk50.4 T Cell Receptor Beta Chain(Gene symbol: TRBC1)
Molecule annotation
Chemicals (5 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB