2E4Y: Crystal Structure Of The Extracellular Region Of The Group Ii Metabotropic Glutamate Receptor Complexed With 2r,4r-Apdc

Metabotropic glutamate receptors play major roles in the activation of excitatory synapses in the central nerve system. We determined the crystal structure of the entire extracellular region of the group II receptor and that of the ligand-binding region of the group III receptor. A comparison among groups I, II, and III provides the structural basis that could account for the discrimination of group-specific agonists. Furthermore, the structure of group II includes the cysteine-rich domain, which is tightly linked to the ligand-binding domain by a disulfide bridge, suggesting a potential role in transmitting a ligand-induced conformational change into the downstream transmembrane region. The structure also reveals the lateral interaction between the two cysteine-rich domains, which could stimulate clustering of the dimeric receptors on the cell surface. We propose a general activation mechanism of the dimeric receptor coupled with both ligand-binding and interprotomer rearrangements.
PDB ID: 2E4YDownload
MMDB ID: 44372
PDB Deposition Date: 2006/12/17
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 3.4  Å
Source Organism:
Similar Structures:
Biological Unit for 2E4Y: dimeric; determined by author
Molecular Components in 2E4Y
Label Count Molecule
Proteins (2 molecules)
Metabotropic Glutamate Receptor 3(Gene symbol: Grm3)
Molecule annotation
Chemicals (3 molecules)
* Click molecule labels to explore molecular sequence information.

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