National Center for
2DUV: Structure Of Cdk2 With A 3-Hydroxychromones
Bioorg. Med. Chem. Lett. (2007) 17 p.1284-1287
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.