2DUV: Structure Of Cdk2 With A 3-Hydroxychromones

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
PDB ID: 2DUVDownload
MMDB ID: 43718
PDB Deposition Date: 2006/7/27
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 2DUV: monomeric; determined by author
Molecular Components in 2DUV
Label Count Molecule
Protein (1 molecule)
Cell Division Protein Kinase 2(Gene symbol: CDK2)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB