2D4R: Crystal Structure Of Ttha0849 From Thermus Thermophilus Hb8

The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
PDB ID: 2D4RDownload
MMDB ID: 36823
PDB Deposition Date: 2005/10/23
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 2D4R: monomeric; determined by author
Molecular Components in 2D4R
Label Count Molecule
Protein (1 molecule)
Hypothetical Protein Ttha0849
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB