2D46: Solution Structure of the Human Beta4a-A Domain

Citation:
Abstract
Ca2+ channel beta subunits regulate trafficking and gating (opening and closing) of voltage-dependent Ca2+ channel alpha1 subunits. Based on primary sequence comparisons, they are thought to be modular structures composed of five domains (A-E) that are related to the large family of membrane associated guanylate-kinase (MAGUK) proteins. The crystal structures of the beta subunit core, B-D, domains have recently been reported; however, very little is known about the structures of the A and E domains. The N-terminal A domain is a hypervariable region that differs among the four subtypes of Ca2+ channel beta subunits (beta1-beta4). Furthermore, this domain undergoes alternative splicing to create multiple N-terminal structures within a given gene class that have distinct effects on gating. We have solved the solution structure of the A domain of the human beta4a subunit, a splice variant that we have shown previously to have alpha1 subunit subtype-specific effects on Ca2+ channel trafficking and gating.
PDB ID: 2D46Download
MMDB ID: 35822
PDB Deposition Date: 2005/10/10
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 2D46
Label Count Molecule
Protein (1 molecule)
1
Calcium Channel, Voltage-dependent, Beta 4 Subunit Isoform a(Gene symbol: CACNB4)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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