2CBX: X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with beta-D-erythrofuranosyl- adenosine

Citation:
Abstract
The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C-F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C-F bond formation.
PDB ID: 2CBXDownload
MMDB ID: 44304
PDB Deposition Date: 2006/1/9
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2CBX: hexameric; determined by author and by software (PQS)
Molecular Components in 2CBX
Label Count Molecule
Proteins (6 molecules)
6
5'-fluoro-5'-deoxyadenosine Synthase
Molecule annotation
Chemicals (24 molecules)
1
6
2
18
* Click molecule labels to explore molecular sequence information.

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