2CAS: The Canine Parvovirus Empty Capsid Structure

The structure of empty canine parvovirus capsids shows that residues 37 to the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of the 60 subunits. The central structural motif of each subunit is the eight-stranded antiparallel beta-barrel that has been found in many other virus structures. Five beta-hairpin turns form a beta-cylindrical structure at each icosahedral 5-fold axis. The N-terminal glycine-rich sequence can be accommodated within this cylinder without excessive steric hindrance, consistent with the electron density distribution. By far the largest conformational differences between the full and empty virus were found in the region where some ordered DNA has been observed to bind in canine parvovirus full particles. Extensive interactions among 3-fold related subunits indicate that a trimeric subunit might be a viral assembly intermediate.
PDB ID: 2CASDownload
MMDB ID: 57910
PDB Deposition Date: 1993/8/24
Updated in MMDB: 2011/12
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 2CAS: 60-meric
Molecular Components in 2CAS
Label Count Molecule
Proteins (60 molecules)
Canine Parvovirus Empty Capsid (Strain D) Viral Protein 2
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB