2C6L: Crystal Structure Of The Human Cdk2 Complexed With The Triazolopyrimidine Inhibitor

Citation:
Abstract
Crystallographic and modelling data, in conjunction with a medicinal chemistry template-hopping approach, led to the identification of a series of novel and potent inhibitors of human cyclin-dependent kinase 2 (CDK2), with selectivity over glycogen synthase kinase-3beta (GSK-3beta). One example had a CDK2 IC(50) of 120 nM and showed selectivity over GSK-3beta of 167-fold.
PDB ID: 2C6LDownload
MMDB ID: 36763
PDB Deposition Date: 2005/11/10
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 2C6L: monomeric; determined by author and by software (PQS)
Molecular Components in 2C6L
Label Count Molecule
Protein (1 molecule)
1
Cell Division Protein Kinase 2(Gene symbol: CDK2)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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