2BSM: Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

PDB ID: 2BSMDownload
MMDB ID: 34017
PDB Deposition Date: 2005/5/23
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 2BSM: dimeric; determined by author and by software (PQS)
Molecular Components in 2BSM
Label Count Molecule
Proteins (2 molecules)
2
Heat Shock Protein Hsp90-alpha
(Gene symbol: HSP90AA1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303