2BRE: STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90

Citation:
Abstract
High-throughput screening identified the 3,4-diarylpyrazole CCT018159 as a novel and potent (7.1 microM) inhibitor of Hsp90 ATPase activity. Here, we describe the synthesis of CCT018159 and a number of close analogues together with data on their biochemical properties. Some initial structure-activity relationships are discussed, as well as the crystal structure of CCT018159 bound to Hsp90.
PDB ID: 2BREDownload
MMDB ID: 35347
PDB Deposition Date: 2005/5/4
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2BRE: monomeric; determined by author and by software (PQS)
Molecular Components in 2BRE
Label Count Molecule
Protein (1 molecule)
1
Atp-dependent Molecular Chaperone Hsp82(Gene symbol: HSP82)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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