2BPV: Hiv-1 Protease-Inhibitor Complex

Citation:
Abstract
The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.
PDB ID: 2BPVDownload
MMDB ID: 9577
PDB Deposition Date: 1998/1/22
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 2BPV: dimeric; determined by author and by software (PISA)
Molecular Components in 2BPV
Label Count Molecule
Proteins (2 molecules)
2
Hiv-1 Protease
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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