2BAT: The Structure Of The Complex Between Influenza Virus Neuraminidase And Sialic Acid, The Viral Receptor

Citation:
Abstract
Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.
PDB ID: 2BATDownload
MMDB ID: 57876
PDB Deposition Date: 1992/8/10
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2BAT: tetrameric; determined by author and by software (PISA,PQS)
Molecular Components in 2BAT
Label Count Molecule
Proteins (4 molecules)
4
Neuraminidase N2
Molecule annotation
Chemicals (28 molecules)
1
20
2
4
3
4
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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