2B7A: The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

PDB ID: 2B7ADownload
MMDB ID: 37130
PDB Deposition Date: 2005/10/4
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 2B7A: monomeric; determined by author
Molecular Components in 2B7A
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303