2B0S: Crystal Structure Analysis Of Anti-Hiv-1 V3 Fab 2219 In Complex With Mn Peptide

Citation:
Abstract
Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
PDB ID: 2B0SDownload
MMDB ID: 39584
PDB Deposition Date: 2005/9/14
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 2B0S: trimeric; determined by author and by software (PISA)
Molecular Components in 2B0S
Label Count Molecule
Proteins (3 molecules)
1
FAB 2219, Light Chain
Molecule annotation
1
FAB 2219, Heavy Chain
Molecule annotation
1
MN Peptide of Exterior Membrane Glycoprotein Gp120
Molecule annotation
Chemicals (5 molecules)
1
2
2
3
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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