2B0S: Crystal Structure Analysis Of Anti-Hiv-1 V3 Fab 2219 In Complex With Mn Peptide

Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.
PDB ID: 2B0SDownload
MMDB ID: 39584
PDB Deposition Date: 2005/9/14
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 2B0S: trimeric; determined by author and by software (PISA)
Molecular Components in 2B0S
Label Count Molecule
Proteins (3 molecules)
FAB 2219, Light Chain
Molecule annotation
FAB 2219, Heavy Chain
Molecule annotation
MN Peptide of Exterior Membrane Glycoprotein Gp120
Molecule annotation
Chemicals (5 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB