2AOA: Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

PDB ID: 2AOADownload
MMDB ID: 35228
PDB Deposition Date: 2005/8/12
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.99  Å
Source Organism:
Similar Structures:
Biological Unit for 2AOA: monomeric; determined by author
Molecular Components in 2AOA
Label Count Molecule
Protein (1 molecule)
1
Growth Factor Receptor-bound Protein 2
(Gene symbol: GRB2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
3
2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID
2
1
3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303