2AJF: Structure Of Sars Coronavirus Spike Receptor-Binding Domain Complexed With Its Receptor

Citation:
Abstract
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.
PDB ID: 2AJFDownload
MMDB ID: 35213
PDB Deposition Date: 2005/8/1
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
SARS coronavirus
Similar Structures:
Biological Unit for 2AJF: dimeric; determined by author and by software (PISA)
Molecular Components in 2AJF
Label Count Molecule
Proteins (2 molecules)
1
Angiotensin-converting Enzyme-related Carboxypeptidase (Ace2)(Gene symbol: ACE2)
Molecule annotation
1
Sars-coronavirus Spike Protein
Molecule annotation
Chemicals (7 molecules)
1
5
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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