2A11: Crystal Structure Of Nuclease Domain Of Ribonuclase Iii From Mycobacterium Tuberculosis

RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.
PDB ID: 2A11Download
MMDB ID: 33974
PDB Deposition Date: 2005/6/17
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 2A11: dimeric; determined by author and by software (PISA,PQS)
Molecular Components in 2A11
Label Count Molecule
Proteins (2 molecules)
Ribonuclease III
Molecule annotation
Chemicals (2 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB