1ZTA: THE SOLUTION STRUCTURE OF A LEUCINE-ZIPPER MOTIF PEPTIDE

Citation:
Abstract
We report the complete structure determination of a 34 residue synthetic peptide with the amino acid sequence of the dimerization domain (leucine zipper) of GCN4. A high resolution structure in solution was obtained by 1H-NMR studies and distance geometry calculations followed by restrained energy minimization. A set of 20 final structures was obtained with an average root mean square deviation of 1.3 A for the backbone atoms (excluding the first and the last two residues). The structure contains an uninterrupted helix. A comparison with a structure previously determined for a larger peptide containing both the DNA-binding region (basic region) and the leucine-zipper motif shows the structural independence of the leucine-zipper domain from the contiguous DNA binding region.
PDB ID: 1ZTADownload
MMDB ID: 57776
PDB Deposition Date: 1990/10/11
Updated in MMDB: 2007/10
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 1ZTA
Label Count Molecule
Protein (1 molecule)
1
Leucine Zipper Monomer(Gene symbol: GCN4)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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