1ZMJ: Crystal Structure Of The Catalytic Domain Of Factor Xi In Complex With 4-(guanidinomethyl)-phenylboronic Acid

Citation:
Abstract
A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.
PDB ID: 1ZMJDownload
MMDB ID: 38960
PDB Deposition Date: 2005/5/10
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1ZMJ: monomeric; determined by author
Molecular Components in 1ZMJ
Label Count Molecule
Protein (1 molecule)
1
Coagulation Factor XI(Gene symbol: F11)
Molecule annotation
Chemicals (4 molecules)
1
2
2
1
3
1
* Click molecule labels to explore molecular sequence information.

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