1Z0R: Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB

Citation:
Abstract
New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily.
PDB ID: 1Z0RDownload
MMDB ID: 32611
PDB Deposition Date: 2005/3/2
Updated in MMDB: 2005/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 1Z0R
Label Count Molecule
Proteins (2 molecules)
2
Transition State Regulatory Protein Abrb(Gene symbol: abrB)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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