1YPQ: Human Oxidized Low Density Lipoprotein Receptor Lox-1 Dioxane Complex

Citation:
Abstract
The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.
PDB ID: 1YPQDownload
MMDB ID: 32133
PDB Deposition Date: 2005/1/31
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 1YPQ: dimeric; determined by author and by software (PISA)
Molecular Components in 1YPQ
Label Count Molecule
Proteins (2 molecules)
2
Oxidised LOW Density Lipoprotein (Lectin-like) Receptor 1(Gene symbol: OLR1)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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