1YMM: TcrHLA-Dr2bMBP-Peptide Complex

Citation:
Abstract
Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different from that of antimicrobial TCRs. Rather than being centered on the peptide-major histocompatibility complex, this TCR contacted only the N-terminal peptide segment and made asymmetrical interactions with the major histocompatibility complex helices. The interaction was dominated by the hypervariable complementarity-determining region 3 loops, indicating that unconventional topologies are possible because of the unique complementarity-determining region 3 sequences created during rearrangement. This topology reduces the interaction surface with peptide and alters the geometry for CD4 association. We propose that unusual TCR-binding properties can permit autoreactive T cells to escape deletion.
PDB ID: 1YMMDownload
MMDB ID: 32929
PDB Deposition Date: 2005/1/21
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
synthetic construct
Similar Structures:
Biological Unit for 1YMM: pentameric; determined by author
Molecular Components in 1YMM
Label Count Molecule
Proteins (5 molecules)
1
HLA Class II Histocompatibility Antigen, DR Alpha Chain(Gene symbol: HLA-DRA)
Molecule annotation
1
HLA Class II Histocompatibility Antigen, DR Beta Chain
Molecule annotation
1
MBP Peptide(Gene symbol: MBP)
Molecule annotation
1
T Cell Receptor Alpha Chain
Molecule annotation
1
T-cell Receptor Beta Chain(Gene symbol: TRBC1)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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