1XE3: Crystal Structure Of Purine Nucleoside Phosphorylase Deod From Bacillus Anthracis

Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
PDB ID: 1XE3Download
MMDB ID: 30163
PDB Deposition Date: 2004/9/9
Updated in MMDB: 2006/12
Experimental Method:
x-ray diffraction
Resolution: 2.24  Å
Source Organism:
Similar Structures:
Biological Unit for 1XE3: hexameric; determined by author and by software (PISA)
Molecular Components in 1XE3
Label Count Molecule
Proteins (6 molecules)
Purine Nucleoside Phosphorylase(Gene symbol: deoD)
Molecule annotation
Chemicals (6 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB