1WV7: Human Factor Viia-tissue Factor Complexed With Ethylsulfonamide-d-5-propoxy-trp-gln-p-aminobenzamidine

Citation:
Abstract
Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs of the P3 moiety in the peptide mimetic factor VIIa inhibitor successfully lead to novel inhibitors with selectivity for FVIIa/TF and extrinsic coagulation the same as or even higher than those of previously reported peptide mimetic factor VIIa inhibitors. X-ray crystal structure analysis reveals that one of the novel inhibitors shows improved selectivity by forming interactions between the inhibitor and FVIIa as expected. Another of the novel inhibitors achieves improved selectivity through an unexpected hydrogen bond with Gln217, with a unique bent conformation in FVIIa/TF accompanied by conformational changes of the inhibitor and the protein.
PDB ID: 1WV7Download
MMDB ID: 36568
PDB Deposition Date: 2004/12/11
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.7  Å
Source Organism:
Similar Structures:
Biological Unit for 1WV7: trimeric; determined by author and by software (PISA)
Molecular Components in 1WV7
Label Count Molecule
Proteins (3 molecules)
1
Coagulation Factor VII(Gene symbol: F7)
Molecule annotation
1
Coagulation Factor VII(Gene symbol: F7)
Molecule annotation
1
Tissue Factor(Gene symbol: F3)
Molecule annotation
Chemicals (12 molecules)
1
1
2
1
3
9
4
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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