1W4N: AGAO covalent complex with Tranylcypromine

Citation:
Abstract
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
PDB ID: 1W4NDownload
MMDB ID: 92656
PDB Deposition Date: 2004/7/27
Updated in MMDB: 2011/08
Experimental Method:
x-ray diffraction
Resolution: 1.65  Å
Source Organism:
Similar Structures:
Biological Unit for 1W4N: dimeric; determined by author and by software (PQS)
Molecular Components in 1W4N
Label Count Molecule
Proteins (2 molecules)
2
Phenylethylamine Oxidase
Molecule annotation
Chemicals (15 molecules)
1
2
2
2
3
2
4
9
* Click molecule labels to explore molecular sequence information.

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