1W3C: Crystal structure of the Hepatitis C Virus NS3 Protease in complex with a peptidomimetic inhibitor

PDB ID: 1W3CDownload
MMDB ID: 31004
PDB Deposition Date: 2004/7/14
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 1W3C: dimeric; determined by author and by software (PISA)
Molecular Components in 1W3C
Label Count Molecule
Proteins (2 molecules)
1
Protease/helicase NS3 (P70)
Molecule annotation
1
Nonstructural Protein Ns4a (P4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-({(2S)-2-[({(1R)-1-[({(1R)-1-[(R)-CARBOXY(HYDROXY)METHYL]-3,3-DIFLUOROPROPYL}AMINO)CARBONYL]-3-METHYLBUTYL}AMINO)CARB ONYL]-2,3-DIHYDRO-1H-INDOL-2-YL}METHYL)THIOPHENE-2-CARBOXYLIC ACID3-({(2S)-2-[({(1R)-1-[({(1R)-1-[(R)-CARBOXY(HYDROXY)METHYL]-3,3-DIFLUOROPROPYL}AMINO)CARBONYL]-3-METHYLBUTYL}AMINO)CARB ONYL]-2,3-DIHYDRO-1H-INDOL-2-YL}METHYL)THIOPHENE-2-CARBOXYLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303