1W2K: Tf7a_4380 Complex

Citation:
Abstract
Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
PDB ID: 1W2KDownload
MMDB ID: 33623
PDB Deposition Date: 2004/7/6
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 1W2K: trimeric; determined by author and by software (PQS)
Molecular Components in 1W2K
Label Count Molecule
Proteins (3 molecules)
1
Blood Coagulation Factor Viia(Gene symbol: F7)
Molecule annotation
1
Blood Coagulation Factor Viia(Gene symbol: F7)
Molecule annotation
1
Tissue Factor(Gene symbol: F3)
Molecule annotation
Chemicals (13 molecules)
1
1
2
9
3
1
4
1
5
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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