1VTY: Crystal Structure Of A Z-Dna Fragment Containing Thymine2- Aminoadenine Base Pairs

The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.
PDB ID: 1VTYDownload
MMDB ID: 91495
PDB Deposition Date: 1988/8/18
Updated in MMDB: 2011/07
Experimental Method:
x-ray diffraction
Resolution: 1.3  Å
Source Organism:
Biological Unit for 1VTY: dimeric; determined by author
Molecular Components in 1VTY
Label Count Molecule
Nucleotide(1 molecule)
DNA (5'-d(*cp*(nh2)ap*cp*gp*tp*g)-3')
Molecule annotation
Chemicals (3 molecules)
* Click molecule labels to explore molecular sequence information.

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