1VSZ: Crystal Structure Of Human Adenovirus At 3.5a

Citation:
Abstract
Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom resolution of the 150-megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions between the major capsid protein (hexon) and several accessory molecules that stabilize the capsid. The virus structure also reveals an altered association between the penton base and the trimeric fiber protein, perhaps reflecting an early event in cell entry. The high-resolution structure provides a substantial advance toward understanding the assembly and cell entry mechanisms of a large double-stranded DNA virus and provides new opportunities for improving adenovirus-mediated gene transfer.
PDB ID: 1VSZDownload
MMDB ID: 87750
PDB Deposition Date: 2010/4/8
Updated in MMDB: 2011/03
Experimental Method:
x-ray diffraction
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 1VSZ: 1200-meric
Molecular Components in 1VSZ
Label Count Molecule
Proteins (1200 molecules)
720
Hexon Protein
Molecule annotation
60
Penton Protein
Molecule annotation
300
Putative Peripentonal Hexon-associated Protein
Molecule annotation
120
Hexon-associated Protein
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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