1VSN: Crystal Structure Of A Potent Small Molecule Inhibitor Bound To Cathepsin K

Based on our previous study with trifluoroethylamine as a P2-P3 amide isostere of cathepsin K inhibitor, further optimization led to identification of compound 22 (L-873724) as a potent and selective non-basic cathepsin K inhibitor. This compound showed excellent pharmacokinetics and efficacy in an ovariectomized (OVX) rhesus monkey model. The volumes of distribution close to unity were consistent with this compound not being lysosomotropic, which is a characteristic of basic cathepsin K inhibitors.
PDB ID: 1VSNDownload
MMDB ID: 45571
PDB Deposition Date: 2007/3/19
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1VSN: monomeric; determined by author
Molecular Components in 1VSN
Label Count Molecule
Protein (1 molecule)
Cathepsin K(Gene symbol: CTSK)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB