1VLK: Structure Of Viral Interleukin-10

The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.
PDB ID: 1VLKDownload
MMDB ID: 57603
PDB Deposition Date: 1997/2/14
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1VLK: dimeric; determined by author and by software (PISA,PQS)
Molecular Components in 1VLK
Label Count Molecule
Proteins (2 molecules)
Viral Interleukin-10(Gene symbol: BCRF1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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