1V3D: Structure Of The Hemagglutinin-Neuraminidase From Human Parainfluenza Virus Type Iii: Complex With Neu5ac2en

Citation:
Abstract
The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface.
PDB ID: 1V3DDownload
MMDB ID: 26298
PDB Deposition Date: 2003/10/30
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.28  Å
Source Organism:
Similar Structures:
Biological Unit for 1V3D: dimeric; determined by author and by software (PISA)
Molecular Components in 1V3D
Label Count Molecule
Proteins (2 molecules)
2
Hemagglutinin-neuraminidase Glycoprotein
Molecule annotation
Chemicals (14 molecules)
1
7
2
2
3
2
4
2
5
1
* Click molecule labels to explore molecular sequence information.

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