1U9W: Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With The Covalent Inhibitor Nvp-abi491

Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.
PDB ID: 1U9WDownload
MMDB ID: 34534
PDB Deposition Date: 2004/8/11
Updated in MMDB: 2012/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 1U9W: monomeric; determined by author
Molecular Components in 1U9W
Label Count Molecule
Protein (1 molecule)
Cathepsin K(Gene symbol: CTSK)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB