1U71: Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

PDB ID: 1U71Download
MMDB ID: 31294
PDB Deposition Date: 2004/8/2
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 1U71: monomeric; determined by author
Molecular Components in 1U71
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: DHFR)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
SULFATE IONSULFATE ION
2
1
6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303