National Center for
1U6Q: Substituted 2-Naphthamadine inhibitors of Urokinase
Bioorg. Med. Chem. Lett. (2005) 15 p.93-98
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.