1U6Q: Substituted 2-Naphthamadine inhibitors of Urokinase

A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus previously described amide-linked inhibitors.
PDB ID: 1U6QDownload
MMDB ID: 30010
PDB Deposition Date: 2004/7/30
Updated in MMDB: 2004/12
Experimental Method:
x-ray diffraction
Resolution: 2.02  Å
Source Organism:
Similar Structures:
Biological Unit for 1U6Q: monomeric; determined by author
Molecular Components in 1U6Q
Label Count Molecule
Protein (1 molecule)
Urokinase-type Plasminogen Activator(Gene symbol: PLAU)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB