1TYU: Structure Of Tailspike-Protein

Citation:
Abstract
The O-antigenic repeating units of lipopolysaccharides from Salmonella serogroups A, B, and D1 serve as receptors for the phage P22 tailspike protein, which also has receptor destroying endoglycosidase (endorhamnosidase) activity, integrating the functions of both hemagglutinin and neuraminidase in influenza virus. Crystal structures of the tailspike protein in complex with oligosaccharides, comprising two O-antigenic repeating units from Salmonella typhimurium, Salmonella enteritidis, and Salmonella typhi 253Ty were determined at 1.8 A resolution. The active-site topology with Asp-392, Asp-395, and Glu-359 as catalytic residues was identified. Kinetics of binding and cleavage suggest a role of the receptor destroying endorhamnosidase activity primarily for detachment of newly assembled phages.
PDB ID: 1TYUDownload
MMDB ID: 51590
PDB Deposition Date: 1996/7/26
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 1TYU: trimeric; determined by author and by software (PISA,PQS)
Molecular Components in 1TYU
Label Count Molecule
Proteins (3 molecules)
3
Tailspike Protein(Gene symbol: 9)
Molecule annotation
Chemicals (21 molecules)
1
6
2
6
3
6
4
3
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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