1TOW: Crystal Structure Of Human Adipocyte Fatty Acid Binding Protein In Complex With A Carboxylic Acid Ligand

Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
PDB ID: 1TOWDownload
MMDB ID: 29065
PDB Deposition Date: 2004/6/15
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1TOW: monomeric; determined by author
Molecular Components in 1TOW
Label Count Molecule
Protein (1 molecule)
Fatty Acid-binding Protein, Adipocyte(Gene symbol: FABP4)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB