1TLZ: Tsx Structure Complexed With Uridine

Citation:
Abstract
Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites, two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening. Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding. Nucleoside transport presumably occurs by diffusion from one binding site to the next.
PDB ID: 1TLZDownload
MMDB ID: 29059
PDB Deposition Date: 2004/6/10
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 1TLZ: monomeric; determined by author
Molecular Components in 1TLZ
Label Count Molecule
Protein (1 molecule)
1
Nucleoside-specific Channel-forming Protein TSX(Gene symbol: tsx)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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