1SSK: Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein

Citation:
Abstract
The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
PDB ID: 1SSKDownload
MMDB ID: 27875
PDB Deposition Date: 2004/3/24
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
Similar Structures:
Molecular Components in 1SSK
Label Count Molecule
Protein (1 molecule)
1
Nucleocapsid Protein(Gene symbol: N)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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