1SMZ: Structure of Transportan in phospholipid bicellar solution

Citation:
Abstract
Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.
PDB ID: 1SMZDownload
MMDB ID: 51369
PDB Deposition Date: 2004/3/10
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Similar Structures:
Molecular Components in 1SMZ
Label Count Molecule
Protein (1 molecule)
1
Transportan in Bicellar Solution With [dmpc]/[dhpc]=0.33
Molecule annotation
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