1SL3: crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor

PDB ID: 1SL3Download
MMDB ID: 28578
PDB Deposition Date: 2004/3/5
Updated in MMDB: 2024/11
Experimental Method:
x-ray diffraction
Resolution: 1.81  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 1SL3: dimeric; determined by author
Molecular Components in 1SL3
Label Count Molecule
Proteins (2 molecules)
1
Thrombin
Molecule annotation
1
Hirudin
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-2-OXOPYRAZIN-1(2H)-YL]-N-[5-CHLORO-2-(1H-TETRAZOL-1-YL)BENZYL]ACETAMIDE(2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-2-OXOPYRAZIN-1(2H)-YL]-N-[5-CHLORO-2-(1H-TETRAZOL-1-YL)BENZYL]ACETAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303