1SHC: SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

Citation:
Abstract
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a beta-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.
PDB ID: 1SHCDownload
MMDB ID: 5947
PDB Deposition Date: 1996/3/27
Updated in MMDB: 2007/11
Experimental Method:
solution nmr
Source Organism:
synthetic construct
Similar Structures:
Molecular Components in 1SHC
Label Count Molecule
Proteins (2 molecules)
1
SHC(Gene symbol: SHC1)
Molecule annotation
1
Trka Receptor Phosphopeptide(Gene symbol: NTRK1)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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