1SAC: The Structure Of Pentameric Human Serum Amyloid P Component

Citation:
Abstract
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
PDB ID: 1SACDownload
MMDB ID: 2151
PDB Deposition Date: 1994/1/27
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1SAC: pentameric; determined by author and by software (PISA)
Molecular Components in 1SAC
Label Count Molecule
Proteins (5 molecules)
5
Serum Amyloid P Component(Gene symbol: APCS)
Molecule annotation
Chemicals (14 molecules)
1
10
2
4
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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