1RZ8: Crystal Structure Of Human Anti-hiv-1 Gp120-reactive Antibody 17b

Citation:
Abstract
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
PDB ID: 1RZ8Download
MMDB ID: 26226
PDB Deposition Date: 2003/12/24
Updated in MMDB: 2016/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 1RZ8: dimeric; determined by author and by software (PISA)
Molecular Components in 1RZ8
Label Count Molecule
Proteins (2 molecules)
1
FAB 17B Light Chain
Molecule annotation
1
FAB 17B Heavy Chain
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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