1RUZ: 1918 H1 Hemagglutinin

Citation:
Abstract
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
PDB ID: 1RUZDownload
MMDB ID: 26943
PDB Deposition Date: 2003/12/12
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 2.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1RUZ: hexameric; determined by author and by software (PISA)
Molecular Components in 1RUZ
Label Count Molecule
Proteins (6 molecules)
3
Hemagglutinin
Molecule annotation
3
Hemagglutinin
Molecule annotation
Chemicals (11 molecules)
1
9
2
2
* Click molecule labels to explore molecular sequence information.

Citing MMDB
.