1R3M: Crystal Structure Of The Dimeric Unswapped Form Of Bovine Seminal Ribonuclease

Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state.
PDB ID: 1R3MDownload
MMDB ID: 25453
PDB Deposition Date: 2003/10/2
Updated in MMDB: 2003/12
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 1R3M: monomeric; determined by author
Molecular Components in 1R3M
Label Count Molecule
Protein (1 molecule)
Ribonuclease, Seminal(Gene symbol: RNASE1)
Molecule annotation
Chemical (1 molecule)
* Click molecule labels to explore molecular sequence information.

Citing MMDB