1R1A: Crystal Structure Of Human Rhinovirus Serotype 1a (Hrv1a)

Citation:
Abstract
The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A resolution using phase refinement and extension by symmetry averaging starting with phases at 5 A resolution calculated from the known human rhinovirus 14 (HRV14) structure. The polypeptide backbone structures of HRV1A and HRV14 are similar, but the exposed surfaces are rather different. Differential charge distribution of amino acid residues in the "canyon", the putative receptor binding site, provides a possible explanation for the difference in minor versus major receptor group specificities, represented by HRV1A and HRV14, respectively. The hydrophobic pocket in VP1, into which antiviral compounds bind, is in an "open" conformation similar to that observed in drug-bound HRV14. Drug binding in HRV1A does not induce extensive conformational changes, in contrast to the case of HRV14.
PDB ID: 1R1ADownload
MMDB ID: 2010
PDB Deposition Date: 1989/3/15
Updated in MMDB: 2011/12
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 1R1A: 240-meric
Molecular Components in 1R1A
Label Count Molecule
Proteins (240 molecules)
60
Human Rhinovirus 1A Coat Protein (Subunit Vp1)
Molecule annotation
60
Human Rhinovirus 1A Coat Protein (Subunit Vp2)
Molecule annotation
60
Human Rhinovirus 1A Coat Protein (Subunit Vp3)
Molecule annotation
60
Human Rhinovirus 1A Coat Protein (Subunit Vp4)
Molecule annotation
Chemicals (60 molecules)
1
60
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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